The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase complex ...

Chemists have developed an organic catalyst that can drive reactions using pyruvate -- a key biomolecule in many metabolic pathways -- that are difficult and complicated to achieve using conventional ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a ...

Cancer metastasis is a crucial area in cancer research that directly affects patient survival and treatment outcomes. Cancer cells often undergo adaptive metabolic changes during metastasis from in ...

Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...