Research into cell cycle regulation and size control in microorganisms has yielded a nuanced understanding of how these entities maintain homeostasis and synchronise growth with division. In both ...

The regulation of the cell cycle is a fundamental process ensuring the accurate replication and division of cells. Central to this regulation are the Cdc25 phosphatases, which activate ...

Cilia are evolutionarily conserved, microtubule-based organelles that project from the surface of most eukaryotic cells and play a central role in sensing ...

Ubiquitination is a crucial post-translational modification process where the small protein ubiquitin is attached to target proteins, marking them for degradation or altering their function. This ...

TGFβ/ACTIVIN-SMAD2/3-EZH2 cooperates with OCT4 and NANOG in self-renewing hPSCs to keep CDKIs in an epigenetically poised state for rapid activation. Upon the initiation of endoderm differentiation ...

The awe-inspiring process of cell division can turn a fertilized egg into a baby -- or a cancerous cell into a malignant tumor. With so much at stake, nature keeps it tightly controlled in a process ...

Arteriovenous malformations, a hallmark of hereditary hemorrhagic telangiectasia, may be driven by endothelial cell-cycle acceleration via CDK6, suggesting potential for repurposing CDK6 inhibitors.

Gene regulation is the process by which cells control the expression of their genes, determining when, where, and to what extent each gene is expressed. It is a fundamental mechanism that allows cells ...