Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease and ...

Initiation of DNA synthesis: a general model from studies with prokaryotes -- Escherichia coli oriC -- Lambda phage origin: a familiar refrain -- Regulatory transcription factors and the initiation of ...

A team of physicists working at the intersection of theory and experiment are shedding new light on the 'teamwork' of molecular motors -- called RNA polymerases (RNAPs) -- that mediate DNA ...

The foundations of life hinge on the precise replication and transcription of DNA and the translation of the resultant messenger RNAs. These processes are responsible for accurately passing down and ...

Mayo Clinic researchers have identified a protein that acts like a traffic controller for DNA, preventing damage during cell division - a discovery that could lead to new cancer therapies, according ...

Mitochondrial deoxyribonucleic acid (mtDNA) is essential for cellular energy production and overall cell function.

When the molecular machinery in our cells gets to work transcribing the genetic information encoded in DNA into messenger RNA (mRNA), it pauses shortly after starting. Known as promoter-proximal ...

Hepatitis B virus (HBV) reactivation is commonly observed in individuals with chronic HBV infection undergoing antineoplastic drug therapy. Paclitaxel (PTX) treatment has been identified as a ...