Phys.org

'Corrective genes' closer thanks to enzyme modification

Scientists from the Université de Montréal and McGill University have re-engineered a human enzyme, a protein that accelerates chemical reactions within the human body, to become highly resistant to ...

Designer enzyme enables yeast to produce custom fatty acids, reducing need for palm oil

Whether they are laundry detergents, mascara, or Christmas chocolate, many everyday products contain fatty acids from palm ...
CU Boulder News & Events

Tuning the Molecular Interaction of Enzymes with Solvents via Polymer Modification

This method uses polymer modifications to tune enzyme activity for increased solubility in non-native solvents. Tuning the miscibility of enzymes in non-native solvent environments has important ...
GEN

Two-Step M6P Antibody Conjugations Sans Enzyme Remodeling

Sanofi has developed a simpler way to create site-specific antibody-to-mannose-6-phosphate (M6P) conjugates that eliminates the need for enzyme remodeling. This more straightforward method makes M6P ...

STORM Therapeutics and AlidaBio Announce Strategic Collaboration to Accelerate Development of Cancer Therapies Targeting RNA Modifications

STORM Therapeutics Ltd. (STORM), the clinical stage company pioneering cellular reprogramming through RNA modifications to treat disease, today announced a strategic collaboration with Alida ...
Nature

Enzyme modification by polymers with solublities that change in response to photoirradiation in organic media

We have synthesized a hybrid subtilisin the solubility of which can be regulated by photoirradiation through coupling with a photoresponsive copolymer that carries spiropyran groups in its side chains ...
Science Daily

Researchers identify enzyme that removes molecular modifications from transfer RNA

The enzyme ALKBH1 can remove molecular modifications from transfer RNA, causing a measurable effect on protein translation in the cell, new research demonstrates. The study sheds new light on how ...

Q&A: What do scientists need to learn next about blocking enzymes to treat disease?

Enzymes are the molecular machines that power life; they build and break down molecules, copy DNA, digest food, and drive ...
JSTOR Daily

Paracatalytic Modification of Aldolase: A Side Reaction of the Catalytic Cycle Resulting in Irreversible Blocking of Two Active-Site Lysyl Residues

Paracatalytic enzyme modifications result from the oxidation of enzyme-substrate carbanions by extrinsic oxidants. During the oxidation of enzyme-activated substrates, transiently reactive ...
JSTOR Daily

RNA modification enzyme TruB is a tRNA chaperone

Cellular RNAs are chemically modified by many RNA modification enzymes; however, often the functions of modifications remain unclear, such as for pseudouridine formation in the tRNA TΨC arm by the ...
EurekAlert!

The discovery of a tRNA modification enzyme that also acts on nucleosides

Archaeosine is synthesized via three steps in tRNA. ArcS, the second-step enzyme, transfers a lysine to preQ 0, which is introduced into tRNA by ArcTGT, the first-step enzyme. The resultant preQ 0-Lys ...