New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...
Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all phosphoevents ...
Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity. GPCRs ...
The adult midgut of the Drosophila fly: The preparation is visible under the microscope due to nuclear staining and endogenous expression of the receptor Mayo. Adhesion GPCRs belong to the large ...
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Decoding the molecular logic of histamine signaling in the brain
Many people are familiar with histamine, a biological molecule, that serves as a key driver of allergic reactions and other ...
A group of researchers has identified the cause of a 'short-circuit' in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases and could lead to development ...
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